Chemicals

Wortmannin can inhibit MLCK and PI3K with IC50 of 0.17 uM and 3 nM. Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. They can alter the catalytic action of the enzyme ...

KU-60019 can inhibit ATM with IC50 of 6.3 nM. Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. They can alter the catalytic action of the enzyme and consequently slow ...

BMS 777607 can inhibit c-Met with IC50 of 20 nM. Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. They can alter the catalytic action of the enzyme and consequently slow ...

PHA-665752 can inhibit c-MET with IC50 of 9 nM. Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. They can alter the catalytic action of the enzyme and consequently slow ...

Imatinib inhibits c-kit, PDGFR and c-ABL by perfectly binding to adenosine triphosphate (ATP)-binding sites of the c-kit protooncogene product, platelet-derived growth factor receptor (PDGFR), and abelson kinase (c-ABL). Enzyme inhibitors are ...

Immune-complex kinase assay shows mTORC2-specific substrate His6-AKT or the mTORC1 substrate His6-S6K is dose dependently inhibited by WYE-687. Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from ...

CCT128930 is a novel ATP-competitive AKT2 inhibitor with IC50 of 6 nM. Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. They can alter the catalytic action of the enzyme ...

Equivalent to the IC50 for wild-type PI3K-alpha, PKI-402 inhibits E545K and H1047R PI3K-alpha mutants with IC50 of 3 nM. Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. ...

YM201636 potently inhibits mammalian PIKfyve with an IC50 of 33 nM but not yeast orthologue Fab1 with an IC50 of 5 uM, exhibiting around 100-fold selectivity for PtdIns3P p110-alpha with an IC50 of 3 uM. Enzyme inhibitors are molecules that interact ...

Honokiol is a biphyl neolignan present in the cones, bark, and leaves of Magnolia grandifloris that displays antiangiogenic, antiinflammatory, and antitumor properties due to the inhibitory effect on the PI3K/Akt pathway. Enzyme inhibitors are ...