OEM No/Model: 944396-07-0
BKM120 (NVP-BKM120) can inhibit p110-alpha, p110-beta, p110-delta and p110-gamma with IC50 of 52 nM, 166 nM, 166 nM and 262 nM. Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. They can alter the catalytic action of the enzyme and consequently slow down, or even stop catalysis. Inhibitors can act in various modes when interacting with the enzyme: reversible or irreversible inhibition, covalent binding or non-covalent binding, as well as specific or nonspecific inhibition. Based on the inhibition kinetics, enzyme inhibition can be categorized into three major types: competitive inhibition, non-competitive inhibition, and uncompetitive inhibition.
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