OEM No/Model: 371942-69-7
YM201636 potently inhibits mammalian PIKfyve with an IC50 of 33 nM but not yeast orthologue Fab1 with an IC50 of 5 uM, exhibiting around 100-fold selectivity for PtdIns3P p110-alpha with an IC50 of 3 uM. Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. They can alter the catalytic action of the enzyme and consequently slow down, or even stop catalysis. Inhibitors can act in various modes when interacting with the enzyme: reversible or irreversible inhibition, covalent binding or non-covalent binding, as well as specific or nonspecific inhibition. Based on the inhibition kinetics, enzyme inhibition can be categorized into three major types: competitive inhibition, non-competitive inhibition, and uncompetitive inhibition.
Related Product Tags:
acetic acid , Alumina Ball , chemical , chemical random , chemicals , Roller Bearing chemical , Filter Paper Chemical , poly vinyl alcohol , soda ash , titanium dioxide , zinc oxide